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KMID : 1059520180620010019
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Journal of the Korean Chemical Society
2018 Volume.62 No. 1 p.19 ~ p.23
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Synthesis of Rhamnazin and Ombuin as Methylated Metabolites of Quercetin
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Jang Jong-Yun
Kang Dong-Wook
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Abstract
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The methylated metabolites of quercetin, rhamnazin and ombuin are highly likely to develop as anticancer and anti-inflammatory agents. In this study, we synthesized rhamnazin through selective methylation of quercetin hydroxyl group, which has not been reported so far. In addition, a new synthetic method was developed to correct the problems of previous synthetic method of ombuin, one of the methylated metabolites of quercetin.
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KEYWORD
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Rhamnazin, Ombuin, Quercetin, Methylation
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